Mineral Area College is located approximately 60 miles, or one hour, southwest of St. Louis. The college is located just off Highway 67 at the Leadington-Park Hills exit. 

From North: Take I-55 South to Exit 174b (Hwy. 67 - Bonne Terre/Farmington). Continue on Highway 67 South for 30 miles. Take the Park Hills/Leadington exit. Turn left and Mineral Area College will be on the left.

From South: Take I-55 North to Exit 150 (Hwy. 32 – Ste Genevieve/Farmington). Turn left onto Highway 32 and continue for 21 miles. Turn right at the stop light onto Karsch Blvd. Continue on Karsch Blvd. for 3 miles and then Karsch Blvd will turn into Highway 67. Make a slight right on to Highway 67 North and continue for 3 miles. Take the Park Hills/Leadington exit. It will be the second Park Hills exit. Turn right and Mineral Area College will be on the left.