The Computer Information Systems department offers the two-year (Associate) degree in one of two majors. Computer Science is a fast-growing major that focuses on computer programming and related skills with an orientation towards mathematics while Information Systems is a major that, while entailing computer programming as well, looks at a number of computer-related skills such as digital multimedia, software applications, and computer hardware and often has a business orientation. Mineral Area College offers these degrees as well as hosting a four-year university (Central Methodist University) that also offers the B.S. in Computer Science on the MAC campus. Generally, Computer Science courses have a CSC prefix, while Computer Information Systems courses have a CIS prefix. Some courses from either the CSC or the CIS areas can be used for either major (Computer Science or Information Systems).

The faculty of the Computer Information Systems Department include: